Among our cancer research studies at DHMC are those of Dr. Richard J. Barth, Jr., who is currently leading three studies.
- Immunotherapy of cancer. We have completed a study where 26 patients received a dendritic cell vaccine after resection of colon cancer metastastic to the liver. Two-thirds of these patients developed an anti-tumor immune response. We are starting studies whereby we are using cryotherapy to induce anti-tumor immunity in mice and in patients with breast cancer.
- Adjuvant radiation therapy for phyllodes tumors of the breast. We have been engaged since 1998 in a study of radiation therapy after resection of malignant phyllodes tumors of the breast. So far, none of the 41 patients enrolled has had a local recurrence, compared to a recurrence rate of 30 percent in non-radiated historical controls.
- Neoadjuvant chemoradiation therapy for pancreas cancer. We have demonstrated that the delivery of chemotherapy and radiation therapy prior to surgery is associated with a lower rate of local recurrence, when compared to chemoradiation therapy after surgery. This also allows some patients whose tumors appear unresectable to undergo surgical resection.