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Research

Neuropsychology faculty research

Our research primarily uses neuropsychological and/or neuroimaging approaches. This includes studies using clinical and experimental neuropsychological measures, fMRI studies (cognition, reward, pain, and motor skills), pharmacologic fMRI (e.g., medications, cannabis), and morphological studies (volume, shape and thickness). An interest in genetic contributions to variability in cognitive and other outcomes in select patient populations is also present among faculty. In addition, we are developing research using EEG, near-infrared spectroscopy (NIRS), and transcranial magnetic stimulation (TMS) in collaboration with Dartmouth faculty in psychiatry, neurology and engineering. Neuropsychology program faculty, with others at Dartmouth, form the Brain Research Network designed to facilitate and support collaborative research.

Current active funded projects include studies of co-occurring schizophrenia and cannabis use, treatment-resistant depression, multiple sclerosis, sport-related concussion, epilepsy, Parkinson’s disease, MCI, and postoperative cognitive dysfunction in older adults. Faculty also have a variety of research interests such as brain tumors, pediatric cancers, traumatic brain injury, schizophrenia, adult ADHD, addictions, trauma, autism spectrum disorders, obesity and bariatric surgery, as well as executive functions and motivation. Neuroimaging research is conducted through the Brain Imaging Laboratory (BIL), directed by a member of the neuropsychology faculty, and the Advanced Imaging Center at DHMC, which houses a research-dedicated MRI system. Faculty are members of the multi-disciplinary Brain Research Network at Dartmouth.

Neuropsychology fellow involvement in research

Our program emphasizes the scientist-practitioner model, thus fellows are expected to engage in both clinical activity and research. The extent of involvement in research is tailored to each fellow’s interests and career goals, though within the two-year fellowship all fellows are expected at minimum to be involved in the development and preparation of at least one report suitable for publication based on their involvement in a research project under the guidance of one of the faculty. This could take the form of a published abstract and corresponding poster presentation, or the co-authoring of a, empirical or review manuscript or book chapter.

Fellow involvement in research may take several forms, depending on the interests of the fellow and faculty, available projects and data sets, as well as projects in development. Some examples of projects in which fellows have been involved and that reflect the diversity of opportunities include:

  • Participating in neuroimaging studies:Fellows become closely involved with an ongoing project including assisting with scanning, and learning about data processing and analysis. In collaboration with faculty, fellows define a hypothesis that can be addressed by the fellow using existing data. For example, fellows have examined fMRI correlates of pain in MS, and subjective working memory in relation to cortical thickness in amnestic MCI.
  • Using archival data sets to examine variables of interest: Some examples include studies examining the profile of executive functions in adults with TBI, exploring embedded test validity indicators in clinical patient samples; and evaluating the relationship between pain and cognitive in patients with multiple sclerosis.
  • Writing a review paper or book chapter on topics such as the role of the cerebellum in executive functions, neuropsychological assessment basics for neuropsychiatrists, and ADHD in emerging adults.
  • Taking advantage of faculty mentorship and available resources to develop a novel neuropsychological measure (e.g., a former postdoc developed a novel telephone based memory test and interview for older adults).
  • On occasion, fellows with very strong research interests that are in line with those of the neuropsychology faculty have submitted grant proposals to support new pilot projects (with Dartmouth faculty mentoring and consent). For example, a former fellow received a local pilot grant to examine the effects of exertion on outcomes in young adults following concussion.

Selected neuropsychology faculty publications

  • Whitfield-Gabrieli, S., Fischer, A.S., Henricks, A.M., Khokhar, J.H., Roth, R.M., Brunette, M.F., & Green, A.I. (in press). Understanding marijuana’s effects on functional connectivity of the default mode network in patients with schizophrenia and co-occurring cannabis use disorder: A pilot investigation. Schizophrenia Research.
  • Schoenberg, M.R., Osborn, K.E., Mahone, E.M., Feigon, M., Roth, R.M., & Pliskin, N.H. (in press). Physician preferences to communicate neuropsychological results: Proposal to reduce communication errors. Archives of Clinical Neuropsychology
  • McLaren, J.L., Barnett, E.R., Concepcion Zayas, M.T., Lichtenstein, J.D., Acquilano, S.C., Schwartz, L.M., Woloshin, S., & Drake, R.E. (in press). Psychotropic medications for highly vulnerable children. Expert Opinion on Pharmacotherapy. DOI: 10.1080/14656566.2018.1445720
  • Mustafi, S.M., Harezlak, J., Kodiweera, C., Randolph, J.S., Ford, J.C., Wishart, H.A., & Wu, Y.C. (2019). Characterizing white matter alternation in multiple sclerosis using neurite density and q-space imaging. Neural Regeneration Research, 14(1), 114-123. doi: 10.4103/1673-5374.243716
  • Light, S.N., Bieliauskas, L.A., & Taylor, S. (2019). Measuring change in anhedonia using the “Happy Faces Task” pre- to post- rTMS treatment in Major Depressive Disorder (MDD). Translational Psychiatry, DOI: https://doi.org/10.1038/s41398-019-0549-8.
  • Light, S.N. (2019). The heterogeneity of empathy: Possible treatment for anhedonia? Frontiers Psychiatry, DOI: https://doi.org/10.3389/fpsyt.2019.00185.
  • Light, S.N., Moran, Z.D., Zahn-Waxler, C. & Davidson, R.J. (2019). The measurement of positive forms of empathy and their relation to hedonic capacity & other depressive symptomatology. Frontiers Psychology, DOI: https://doi.org/10.3389/fpsyg.2019.00815.
  • Mirabito, G., Taiwo, Z, Bezdek, M. & Light, S.N. (2019). Fronto-striatal activity predicts anhedonia and positive empathy subtypes. Brain Imaging and Behavior, DOI: https://doi.org/10.1007/s11682-019-00081-z.
  • Gooding, D.C., Zahn-Waxler, C., Light, S.N., Kestenbaum, C., & Erlenmeyer-Kimling, L. (2018). Affective indicators of risk for adulthood psychopathology during childhood: Findings from the New York High-Risk Project. Journal of Psychiatry and Brain Science, DOI: https://doi.org/10.20900/jpbs.20180004.
  • Chamard, E. & Lichtenstein, J.D. (2018). A systematic review of neuroimaging findings in children and adolescents with sports-related concussion. Brain Injury, DOI: 10.1080/02699052.2018.1463106.
  • Lazar, D.J., Lichtenstein, J.D., & Tybor, D. (2018). A first look at concussion prevalence in competitive ultimate Frisbee players. Orthopaedic Journal of Sports Medicine, 6(3), DOI: 10.1177/2325967118759051.
  • Lichtenstein, J.D., Erdodi, L., Rai, J., Mazur-Mosiewicz, A., & Flaro, L. (2018). Wisconsin Card Sorting Test embedded validity indicators developed for adults can be extended to children. Child Neuropsychology, 24(2), 247-260. DOI:10.1080/09297049.2016.1259402
  • Light, S.N., Bieliauskas, L.A., & Zubieta, J-K. (2017). “Top-down” mu-opioid system in humans: Mu-opioid receptors in ventrolateral prefrontal cortex mediate the relationship between hedonic tone and executive function in Major Depressive Disorder (MDD). Journal of Neuropsychiatry and Clinical Neurosciences, DOI: https://doi.org/10.1176/appi.neuropsych.16090171.
  • Lin, G., & Roth, R.M. (2017). The status of structural and functional MRI in adolescents with attention-deficit/hyperactivity disorder. Psychological Injury and Law, 10, 209-222.
  • Abecassis, M., Isquith, P.K., & Roth, R.M. (2017). Characteristics of ADHD in the emerging adult: An overview. Psychological Injury and Law, 10, 197–208.
  • Erdodi, L.A., & Lichtenstein, J.D. (2017). Invalid before impaired: an emerging paradox of embedded validity indicators. The Clinical Neuropsychologist, 31(6-7), 1029-1046.
  • Donnelly, K.Z., Linnea, K.S., Grant, D.A., & Lichtenstein, J.D. (2017). The impact of a yoga and meditation pilot programme on the quality of life of adults with acquired brain injury. Brain Injury 31(2):208-214.
  • Lichtenstein, J.D., Linnea, K.S., & Maerlender, A.C. (2017). Patterns of referral in high school concussion management programs: A pilot study of consultants from different disciplines. Applied Neuropsychology: Child, 28,1-8
  • Erdodi, L., Tyson, B., Shahein, A., Lichtenstein, J., Abeare, C., Pelletier, C., Zuccato, B., Kurcharski, B., & Roth, R. (2017). The power of timing: adding a time-to-completion cutoff to the Word Choice Test and Recognition Memory Test improves classification accuracy. The Journal of Clinical and Experimental Neuropsychology, 39(4):369-383.
  • Randolph, J.J., Randolph, J.S., Wishart HA. (2017). Association between cognitive complaints and vulnerability to environmental distraction in multiple sclerosis. Archives of Clinical Neuropsychology, 32(1), 21-28.
  • McLaren, J., Lichtenstein, J.D., Lynch, D., Becker, D., & Drake, R. (2017). Individual placement and support for people with autism spectrum disorders: a pilot program. Administration and Policy in Mental Health and Mental Health Services Research. DOI: 10.1007/s10488-017-0792-3
  • Rai, J., Abecassis, M., Casey, J.E., Flaro, L., Erdodi, L., & Roth, R.M. (2017). Parent rating of executive function in fetal alcohol spectrum disorder: A review of the literature and new data in aboriginal Canadian children. Child Neuropsychology, 23(6), 713–732.
  • Erdodi, L. & Roth, R.M. (2017). Low scores on BDAE Complex Ideational Material are associated with invalid performance in adults without aphasia. Applied Neuropsychology: Adult, 24(3): 264-274.
  • Fogarty, J., Almklov, E., Borrie, M., Wells, J., & Roth, R.M. (2017). Subjective rating of executive functions in mild Alzheimer’s disease. Aging and Mental Health, 21(11), 1184-1191.
  • Drag, L.L., Light, S.N., Langenecker, S.A., Hazlett, K.E., Wilde, E.A., Welsh, R., Steinberg, B.A. & Bieliauskas, L.A. (2016). Patterns of frontoparietal activation as a marker for unsuccessful visuospatial processing in healthy aging. Brain Imaging and Behavior, DOI https://doi.org/10.1007/s11682-015-9428-y.
  • Schwartz, E.B., Erdodi, L., Ghosh, J.J., Curtain, J.R., Flashman, L. A., & Roth, R.M. (2016). The CVLT-II forced choice recognition trial as an embedded validity indicator: A review of the evidence. Journal of the International Neuropsychological Society, 22(8):851-8.
  • Bujarski, K.A., Flashman, L.A., Zhongze, L., Jobst, B.C., & Roth, R.M. (2016). Investigating social cognition in epilepsy using a naturalistic task. Epilepsia, 57(9), 1515-20.
  • Kahn P.V., Wishart H.A., Randolph J.S., & Santulli (2016). Caregiver stigma and burden in memory disorders: An evaluation of the effects of caregiver type and gender. Curr Gerontol Geriatr Res. doi: 10.1155/2016/8316045.
  • Lichtenstein, J.D., Erdodi, L., & Linnea, K. (2017). Introducing a forced-choice recognition task to the California Verbal Learning Test – Children’s version. Child Neuropsychology, 23(3):284-299.
  • Erdodi, L.A., Lichtenstein, J.D., Rai, J.K., & Flaro, L. (2016). Embedded validity indicators in Conners’ CPT-II: Do adult cutoffs work the same way in children? Applied Neuropsychology: Child, DOI: 10.1080/21622965.2016.1198908.
  • Roth, R.M. & Flashman, L.A. (2016). Psychopathology and psychiatric comorbidity. In Donders, J. (Ed.), Neuropsychological Report Writing. The Guilford Press, pp. 118-142
  • Roth, R.M., Garlinghouse, M.A., Flashman, L.A., Koven, N.S., Pendergrass, J.C., Ford, J.C., McAllister, T.W., & Saykin, A.J. (2016). Apathy is associated with ventral striatum volume in schizophrenia-spectrum disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 28, 191–194.
  • Light, S.N., Moran, Z.D., Swander, L., Le, V., Cage, B., Burghy, C., Westbrooke, C., Greishar, L. & Davidson, R.J. (2015). Electromyographically assessed empathic concern and empathic happiness predict increased prosocial behavior in adults. Biological Psychology, 104, 116-129.
  • Roth, R.M., Erdodi, L., McCullugh, L., & Isquith, P.K. (2015). Much ado about norming: The Behavior Rating Inventory of Executive Function. Child Neuropsychology, 21, 225-233.
  • Moser, R.S., Schatz, P., & Lichtenstein, J.D. (2015). The importance of proper administration and interpretation of neuropsychological baseline and post-concussion computerized testing. Applied Neuropsychology: Child, 4(1), 41-48.
  • Maerlender, A.C., Lichtenstein, J.D., Rieman, W., & Condiracci, C. (2015). Programmed physical exertion in recovery from sport-related concussion. Developmental Psychology. 40(5), 273-8.
  • Lichtenstein, J.D., Moser, R.S., & Schatz, P. (2014). Age and test setting affect the prevalence of invalid baseline scores on neurocognitive testing. American Journal of Sports Medicine, 42(2), 479-84.
  • Madhoo, M., Keefe, R.S., Roth, R.M., Sambunaris, A., Wu, J., Madhukar, H., Trivedi, M., Anderson, C., & Lasser, R. (2014). Lisdexamphetamine dimesylate augmentation in adults with persistent executive dysfunction after partial or full remission of major depressive disorder. Neuropsychopharmacology, 39, 1388-1398.
  • Fischer, A.S., Whitfield-Gabrieli, S., Roth, R.M., Brunette, M.F., & Green, A.I. (2014). Impaired functional connectivity of brain reward circuitry in patients with schizophrenia and cannabis use disorder: Effects of cannabis and THC. Schizophrenia Research, 158, 176-182.
  • Brown, F.C., Katz, L.J., Roth, R.M., & Beers, S.R. (2014). The relationship of self-reported subclinical obsessive-compulsive symptoms and impulsivity among adults with ADHD. Psychiatry Research, 216, 131-136.
  • Defina, P.A., Moser, R.S., Glenn, M., Lichtenstein, J.D., & Fellus, J. (2013). Alzheimer’s disease clinical and research update for health care practitioners. Journal of Aging Research, vol. 2013, Article ID 207178, 9 pages.
  • Risacher, S.L., Wang, Y., Wishart, H.A., Rabin, L.A., Flashman, L.A., McDonald, B.C., West, J.D., Santulli, R.B., & Saykin, A.J. (2013). Cholinergic enhancement of brain activation in Mild Cognitive Impairment (MCI) during episodic memory encoding. Frontiers in Neuropharmacology, 4, 1-20.
  • Roth, R.M., Lance, C.E., Isquith, P.K., Fischer, A.S., & Giancola, P.R. (2013). Confirmatory factor analysis of the Behavior Rating Inventory of Executive Function-Adult version in healthy adults and application to attention-deficit/hyperactivity disorder. Archives of Clinical Neuropsychology, 28, 425-434.
  • Isquith, P.K., Roth, R.M., & Gioia, G.A. (2013). Contributions of rating scales to the assessment of executive functions. Applied Neuropsychology: Child, 2(2): 125-132.
  • Bujarski, K.A., Hirashima, F., Roberts, D.W., Jobst, B.C., Gilbert, K.L., Roth, R.M., Flashman L.A., McDonald, B.C. Saykin, A.J., Scott, R.C., Dinnerstein, E., Preston, J., Williamson, P.D., & Thadani, V.M. (2013). Long-term seizure, cognitive, and psychiatric outcome following trans-middle-temporal gyrus amygdalohippocampectomy and standard temporal lobectomy. Journal of Neurosurgery, 119(1):16-23.
  • Wang, Y., West, J.D., Flashman, L.A., Wishart, H.A., Santulli, R.B., Rabin, L.A., Pare, N., Arfanakis, K., & Saykin, A.J. (2012). Selective changes in white matter integrity in MCI and older adults with cognitive complaints. BBA: Molecular Basis of Disease, 1822, 423-420.
  • Lazow, S. P., Thadani, V.M., Gilbert, K.L., Morse, R.P., Bujarski, K.A., Kulandaivel, K., Roth, R.M., Scott, R.C., Roberts, D.W., & Jobst, B.C. (2012). Outcome of frontal lobe epilepsy surgery. Epilepsia, 53(10), 1746-1755.

Additional details about our research and staff

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