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Medical Renal Pathology

The Renal Biopsy Service at Dartmouth-Hitchcock Medical Center provides detailed diagnostic workups and reports for the entire gamut of adult and pediatric medical renal diseases in the native and the transplant kidney. A routine panel of histochemical stains is employed for light microscopy. The routine direct immunofluorescence staining panel on frozen sections includes IgG, IgA, IgM, C3, C1q, kappa, lambda, fibrinogen, and albumin; indirect IF for C4d is routinely performed on all renal transplant biopsies. (The pronase digestion method is available for IF staining on paraffin embedded tissue when necessary). Transmission electron microscopy is performed at the Rippel Electron Microscopy facility at the Geisel School of Medicine at Dartmouth.

Specialized testing is available for specific diseases, including quantitative basement membrane measurements for thin basement membrane disease, collagen IV subtyping for Alport syndrome, PLA2R staining for membranous nephropathy, and IgG4 staining for IgG4 nephropathy. Prepared kits with appropriate fixatives and transport media are available for the collection of specimens from off-site. The submitting nephrologist is contacted by telephone with preliminary diagnostic information within 24 hours of receipt of the biopsy specimen. The Renal Biopsy Service supports monthly biopsy and curriculum conferences and regular interinstitutional video conferences with Beth Israel Hospital in Boston.

Our Medical Renal Pathology Team

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